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Objectives: The present study was designed to assess whether changes in NT-proBNP levels after mitral, aortic and double valve replacement reflect changes in HF manifestations including NYHA class and changes in LA size, LV size and LV functions. Methods: The study population consisted of 24 patients (mean age: 55.3 ± 16.2 years, 58% were males) underwent surgical mitral valve Replacement (12 patients), Aortic valve replacement (8 patients) and combined mitral and aortic valve replacement (4 patients). Serial NT-proBNP measurements, transthoracic Echocardiography and (NYHA) class assessment were performed before and 6 months after surgery. Results: The decrease in NT-proBNP was associated with decrease in LAD (r = 0.73, p< 0.002), LVESD (r = 0.65, p= 0.001), LVED (r = 0.53, p= 0.036), and increase in EF (r = 0.65, p= 0.001). Decreasing NT-proBNP was associated with improvement in NYHAFC. Conclusion: NT-proBNP levels after mitral, aortic and double valve replacement correlate with changes in heart failure manifestations as well as changes in left atrial size and ventricular dimensions and function.

SHA 037. Correlation between plasma pro-BNP levels and changes in heart failure manifestations, left ventricular size and function