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Acute pancreatitis (AP) is one of the most common gastrointestinal disorders, with a reported annual incidence of 13--45 cases per 100,000 persons.1,2 It is a complex disease that can vary from a mild self-limited presentation, in approximately 80--90% of patients, to a clinically severe form in 10--20% with multiple complications and a mortality rate up to 30%.2--5 Timely identification of patients with clinically severe AP and worse prognosis is important because they may benefit from prompt admission to a dedicated intensive or intermediate care unit, with close monitoring for the development of organ failure, they should receive aggressive fluid resuscitation and targeted therapy such as enteral feeding, endoscopic sphincterotomy, or antibiotics.4,5 Severity stratification is also important when reporting and evaluating the results of clinical trials in AP. The Atlanta Classification has been considered the global standard tool for the assessment of AP severity since its establishment in 1992.6 However, this classification was somehow confusing and, in 2012, it was revised with a

Predictors of Severity and In-Hospital Mortality for Acute Pancreatitis: Is There Any Role for C-Reactive Protein Determination in the First 24 Hours?