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Melatonin has a protective role in adults with cardiovascular disease, but the effects of melatonin in children with cardiac dysfunction are not well understood. This study was designed to explore the variations in melatonin, myeloperoxidase, and caspase-3 levels in children suffering from heart failure.

Serum levels of melatonin may contribute to the pathogenesis of heart failure in children with median age of 1 year