Open AccessPredictive value of immunohistochemical expression of claudin-1 in colonic carcinoma
Author(s) -
Eman Abdelzaher,
Azza M. Rizk,
Samer S. Bessa,
Khalafalla Mustafa Omer
Publication year - 2011
Publication title -
journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2011.10.002
Subject(s) - medicine , claudin , immunohistochemistry , colonic carcinoma , value (mathematics) , carcinoma , expression (computer science) , pathology , oncology , gastroenterology , cancer research , tight junction , microbiology and biotechnology , biology , statistics , computer science , mathematics , programming language
Colonic carcinoma is one of the most common cancers worldwide. Recently, the possible involvement of claudin-1, one of the major tight junction proteins, in the process of tumorigenesis has been suggested. Also, claudin-1 has emerged as a potential prognostic factor in different types of tumors. The aim of this study was to detect caludin-1 expression in colonic carcinoma and to correlate its expression with clinicopathological variables in an attempt to delineate its role as a potential new prognostic marker.
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