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Multiexponential T2 (MET2) Relaxometry and Magnetization Transfer (MT) areamong the most promising MRI-derived techniques for white matter (WM)characterization. Both techniques are shown to have histologically correlatedsensitivity to myelin, but these correlations are not fully understood.Furthermore, MET2 and MT reports on different features of WM, thus beingspecific to different (patho)physiological states. Two-dimensional studies,such as those commonly used in NMR, have been rarely performed in this context.Here, off-resonance irradiation effects on MET2 components were evaluated infixed rat spinal cord white matter at 16.4T. These 2D MT-MET2 experimentsreveal that MT affects both short and long T2 in a tract-specific fashion. Thespatially distinct modulations enhanced contrast betweenmicrostructurally-distinct spinal cord tracts. Two hypotheses to explain thesefindings were proposed: either selective elimination of a short T2 componentthrough pre-saturation is combined with intercompartmental water exchangeeffects that occur on the timescale of irradiation; or other macromolecularspecies that exist within the tissue - other than myelin - such asneurofilaments, may be involved in the apparent microstructural segregation ofthe spinal cord (SC) from MET2. Though further investigation is required toelucidate the underlying mechanism, this phenomenon adds a new dimension for WMcharacterization.

Two-dimensional Magnetization-Transfer - CPMG MRI reveals tract- specific signatures in fixed rat spinal cord