Open AccessFeatures and outcome of AIH patients without elevation of IgG
Author(s) -
Johannes Hartl,
Rosa Miquel,
Kalliopi Zachou,
GuanWee Wong,
Asma Asghar,
Simon Pape,
Marcial Sebode,
Moritz Peiseler,
Roman Zenouzi,
Hanno Ehlken,
Till Krech,
Christina WeilerNormann,
Joost P.H. Drenth,
Ye Htun Oo,
George Ν. Dalekos,
Michael A. Heneghan,
Christoph Schramm,
Ansgar W. Lohse
Publication year - 2020
Publication title -
jhep reports
Language(s) - English
Resource type - Journals
ISSN - 2589-5559
DOI - 10.1016/j.jhepr.2020.100094
Subject(s) - elevation (ballistics) , outcome (game theory) , medicine , mathematics , geometry , mathematical economics
A characteristic feature of autoimmune hepatitis (AIH) is an elevation of immunoglobulin G (IgG), which is therefore used as a major diagnostic criterion, as well as to monitor treatment response. Nevertheless, normal IgG does not preclude the diagnosis of AIH. Therefore, we herein assessed the features of patients with AIH and normal IgG in a large multicentre study. This study demonstrates that about 10% of all patients with AIH have normal IgG; these patients are indistinguishable from other patients with AIH with respect to biochemical markers, liver histology, disease severity and treatment response, but might represent a subgroup with a higher chance of remission after drug withdrawal.
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