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Posttransplant lymphoproliferative disorder (PTLD) describes a varied group of lymphoid proliferative processes that affect immunosuppressed solid organ and bone marrow transplant recipients. Approximately 70% of PTLD cases are related to Epstein-Barr virus (EBV) infection, and the average onset is 8.2 years after transplant.1 Plasmacytoma-like PTLD is a particularly rare monomorphic form of PTLD with plasmacytic differentiation. There are very few cases in the literature describing cutaneous manifestations of plasmacytoma-like PTLD.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 We report a unique case of cutaneous EBV-negative plasmacytoma-like PTLD presenting 25 years after renal transplant, responsive to reduced immunosuppression and topical imiquimod 5% cream.

jaad case reports

Cutaneous plasmacytoma-like posttransplant lymphoproliferative disorder after renal transplantation with response to imiquimod 5% cream and reduced immunosuppression