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BCC: basal cell carcinoma Hh: Hedgehog INTRODUCTION Basal cell carcinoma (BCC) is the most common type of skin cancer. Vismodegib has emerged as a new therapeutic option in metastatic or locally advanced BCC. Vismodegib has several side effects including alopecia, mucosal involvement, and tumor formation. The tumorigenicity potential of vismodegib has been identified only in rats and is limited to benign hair follicle tumors, including pilomatricomas and keratoacanthomas. However, these tumors have not been reported in humans. We present the case of a vismodegib-treated patient who developed a pilomatricoma in a residual scar.

Pilomatricomas secondary to treatment with vismodegib