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MI: malignant intertrigo PPE: palmoplantar erythrodysesthesia SDRIFE: symmetrical drug-related intertriginous, flexural exanthema TEC: toxic erythema of chemotherapy INTRODUCTION Toxic erythema of chemotherapy (TEC) encompasses a broad spectrum of cytotoxic effects on the skin. Despite increasing awareness of TEC, such eruptions may remain unrecognized and subsequently result in unnecessary hospitalizations. Of the different variants of TEC, intertriginous eruptions have been reported using many terms, such as intertrigo dermatitis, intertriginous eruption of chemotherapy, flexural erythematous eruption, and intertrigo-like eruption associated with chemotherapy. Intertrigo is a broad term that refers to any inflammatory rash of closely opposed skin, typically presenting with varying degrees of erythema and maceration, and this particular type of TEC has not been identified with consistent nomenclature. We present 6 cases of this distinct subset of TEC, all occurring within a 7-month period at a single institution; these cases were initially unrecognized, resulted in hospitalization, and required inpatient dermatologic consultation to achieve a diagnosis. Although TEC is a clinically useful term intended to improve discernment of its noninfectious and nonallergic etiology, the loss of morphologic specificity may prevent its variants from being properly recognized, especially in the intertriginous regions. We therefore proposemalignant intertrigo (MI) as a useful and encompassing term describing toxic erythema of chemotherapy affecting the intertriginous skin.

Malignant intertrigo: A subset of toxic erythema of chemotherapy requiring recognition