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Cutaneous reticulohistiocytosis is a rare form of non-Langerhans cell histiocytosis.1 Zak2 originally coined the term reticulohistiocytosis, which is now used to describe the histologic pattern of multinucleate giant cells and oncocytic macrophages showing abundant eosinophilic, finely granular cytoplasm with a ground glass appearance.1 Clinically, reticulohistiocytomas represent asymptomatic, yellow to red-brown or grey-white papules or nodules, which tend to be solitary.3 Solitary reticulohistiocytomas are regarded as benign and are found to occur more commonly in young males but with no predilection as to location.3 Reticulohistiocytomas are rarely reported to occur in crops, then termed multiple reticulohistiocytomas. These crops show no predilection to age, sex, or location and are thought to be benign with the ability to spontaneously regress.4, 5, 6 In contrast, multicentric reticulohistiocytosis is a well-recognized systemic and aggressive form of reticulohistiocytosis, which typically presents in middle-age women with multiple widespread reticulohistiocytomas and associated severe arthritis. This disease can involve multiple organ systems and is usually progressive, necessitating treatment with systemic agents.7 Unlike solitary or multiple reticulohistiocytoma, multicentric reticulohistiocytosis can represent a paraneoplastic phenomenon, with up to 25% of cases being associated with an underlying internal malignancy.8

jaad case reports

Multiple cutaneous reticulohistiocytomas successfully treated with topical psoralen plus ultraviolet A therapy combined with intralesional injections of triamcinolone acetonide