Open AccessCD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing
Author(s) -
Laura Farr,
Swagata Ghosh,
a Jiang,
Kôji Watanabe,
Mahmut Parlak,
Richard Bucala,
Shan Moonah
Publication year - 2020
Publication title -
cellular and molecular gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.417
H-Index - 38
ISSN - 2352-345X
DOI - 10.1016/j.jcmgh.2020.01.009
Subject(s) - regeneration (biology) , inflammation , wound healing , tissue repair , intestinal epithelium , epithelium , microbiology and biotechnology , medicine , biology , immunology , pathology
The inflammatory response to intestinal damage promotes healing through mechanisms that are incompletely understood. Gene expression of cluster of differentiation 74 (CD74), the receptor for cytokine macrophage migration inhibitory factor, is increased in patients with inflammatory bowel disease (IBD), however, the role of CD74 signaling in intestinal inflammation remains poorly understood. The aim of this study was to determine the functional role of CD74 signaling in intestinal inflammation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom