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Exclusive enteral nutrition (EEN), ie, restricting patients to commercially available liquid diets with avoidance of solid food, is an effective treatment for Crohn’s disease (CD). However, commercial formulasused forEENgenerally have low fiber and high sugar content and contain emulsifiers that worsen colitis in animal models. Despite its efficacy, EEN appears to accentuate microbial changes observed in CD, specifically a loss of protective anaerobes and the growth of pathogens. Plant-based enteral nutrition (PBEN) represents a high-fiber alternative to conventional enteral nutrition (CEN) without added sugar or artificial ingredients. The advent of commercially available PBEN is relevant to inflammatory bowel disease because diets low in fruits and vegetables represent a risk factor for CD, and because many plantderived compounds are therapeutic in preclinical colitis models. We sought to determine the effects of PBEN on the microbiota and outcomes in murine colitis models. We initially observed that male C57BL/6 mice randomized to receive PBEN (Liquid Hope; Functional Formularies,

Plant-based Enteral Nutrition Modifies the Gut Microbiota and Improves Outcomes in Murine Models of Colitis