Open AccessEnvironmental Enteric Dysfunction Includes a Broad Spectrum of Inflammatory Responses and Epithelial Repair Processes
Author(s) -
Jinsheng Yu,
M. Isabel Ordiz,
Jennifer L. Stauber,
Nurmohammad Shaikh,
Indi Trehan,
Erica K. Barnell,
Richard D. Head,
Kenneth Maleta,
Phillip I. Tarr,
Mark Manary
Publication year - 2015
Publication title -
cellular and molecular gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.417
H-Index - 38
ISSN - 2352-345X
DOI - 10.1016/j.jcmgh.2015.12.002
Subject(s) - biology , transcriptome , immune system , rna , microbiology and biotechnology , immunology , gene expression , genetics , gene
Environmental enteric dysfunction (EED), a chronic diffuse inflammation of the small intestine, is associated with stunting in children in the developing world. The pathobiology of EED is poorly understood because of the lack of a method to elucidate the host response. This study tested a novel microarray method to overcome limitation of RNA sequencing to interrogate the host transcriptome in feces in Malawian children with EED.
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