Open AccessImproved assay performance of single nucleotide polymorphism array over conventional karyotyping in analyzing products of conception
Author(s) -
Shaobin Lin,
Yingjun Xie,
Zheng Chen,
Yi Zhou,
Jianzhu Wu,
Zhiqiang Zhang,
Shanshan Shi,
Baojiang Chen,
Qun Fang
Publication year - 2015
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1016/j.jcma.2015.03.010
Subject(s) - karyotype , products of conception , uniparental disomy , snp array , single nucleotide polymorphism , snp , genetics , concordance , chromosome , trisomy , copy number variation , biology , miscarriage , medicine , genotype , genome , pregnancy , abortion , gene
Conventional karyotyping has been a routine method to identify chromosome abnormalities in products of conception. However, this process is being transformed by single nucleotide polymorphism (SNP) array, which has advantages over karyotyping, including higher resolution and dispensing with cell culture. Therefore, the purpose of this study was to evaluate the advantage of high-resolution SNP array in identifying genetic aberrations in products of conception.
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