Open AccessA traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation
Author(s) -
Wei Zhao,
Wangying Hu,
Xiaolong Wang,
Nan Xia,
HU Qi-xiang,
Hua Zhou
Publication year - 2015
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1016/j.jcma.2015.03.006
Subject(s) - medicine , perindopril , histone deacetylase , trichostatin a , pharmacology , histone , western blot , heart failure , endocrinology , biochemistry , blood pressure , biology , gene
Chronic heart failure (CHF) is a complex clinical syndrome, and a serious stage of various heart diseases. Dysfunction of histone acetylation is involved in pathogenesis of CHF. Lujiao is a clinical and traditional prescription that has been previously used in the treatment of heart failure. The objective of our study was to explore the effects of traditional Chinese Medicine intervention with Lujiao prescription on hypertrophic cardiomyocytes with histone acetylation abnormality.
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