Open AccessSilencing the expression of Cbl-b enhances the immune activation of T lymphocytes against RM-1 prostate cancer cells in vitro
Author(s) -
Shukui Zhou,
Weihua Chen,
Zheng-Duo Shi,
Shun-Ping Wang,
Liang Li,
Xiaofei Wen,
Yuemin Wang
Publication year - 2014
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1016/j.jcma.2014.03.008
Subject(s) - il 2 receptor , cytotoxic t cell , microbiology and biotechnology , transfection , lymphocyte , immune system , cancer research , tcirg1 , medicine , small interfering rna , biology , immunology , t cell , cell culture , in vitro , biochemistry , genetics
The ubiquitin ligase Cbl-b potently modulates T lymphocyte immune responses and is critical in modulating tumor-induced immunosuppression. The influence of Cbl-b in modulating T lymphocyte activity against prostate cancer remains ill defined. We have determined the effects of silencing Cbl-b expression in T lymphocytes and their subsequent cytotoxic activity against prostate cancer cells.
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