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Inactivation of p16 by methylation of CpG islands is a frequent early event in human cancers, including papillary thyroid carcinoma (PTC). This study was to observe the methylation status of the p16 gene in papillary thyroid carcinoma (PTC) and its correlation with clinical parameters.

Methylation of p16 CpG islands correlated with metastasis and aggressiveness in papillary thyroid carcinoma