Open AccessExploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway
Author(s) -
Ruben D. Addie,
Yvonne de Jong,
Gaia Alberti,
Alwine B. Kruisselbrink,
Ivo Que,
Hans J. Baelde,
Judith V.M.G. Bovée
Publication year - 2019
Publication title -
journal of bone oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 24
eISSN - 2212-1374
pISSN - 2212-1366
DOI - 10.1016/j.jbo.2019.100222
Subject(s) - medicine , metabolome , pi3k/akt/mtor pathway , chondrosarcoma , cancer research , bioinformatics , computational biology , signal transduction , oncology , genetics , pathology , metabolite , biology
mTOR inhibition leads to a reduction of oxidative and glycolytic metabolism and decreased proliferation in chondrosarcoma cell lines. Although further research is needed, these findings suggest that mTOR inhibition might be a potential therapeutic option for patients with chondrosarcoma.
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