Open AccessAngiostrongyliasis detected by next-generation sequencing in a ELISA-negative eosinophilic meningitis: A case report
Author(s) -
Yueli Zou,
Hongzhi Guan,
Honglong Wu,
Hui Bu,
Li-Tian Yan,
Yifei Zhu,
Junying He
Publication year - 2020
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2020.05.108
Subject(s) - angiostrongylus cantonensis , paragonimus westermani , angiostrongyliasis , trichinella spiralis , meningitis , biology , cerebrospinal fluid , microbiology and biotechnology , virology , paragonimiasis , pathology , immunology , medicine , helminths , psychiatry
Next-generation sequencing (NGS) is an emerging method with the potential of pan-pathogen screening. This study described a case of eosinophilic meningitis (EoM) with enzyme-linked immunosorbent assay (ELISA)-negative results for Angiostrongylus cantonensis (A. cantonensis), Trichinella spiralis and Paragonimus westermani and a positive identification of A. cantonensis by NGS in the cerebrospinal fluid.
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