Open AccessIncreasing multidrug and fluoroquinolone resistance among Salmonella Typhi from sporadic outbreaks in Kenya
Author(s) -
Sanam Kavai,
Samuel Kariuki
Publication year - 2019
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2018.11.119
Subject(s) - salmonella typhi , typhoid fever , ciprofloxacin , medicine , outbreak , ampicillin , tetracycline , nalidixic acid , multiple drug resistance , salmonella , antibiotic resistance , incidence (geometry) , drug resistance , veterinary medicine , microbiology and biotechnology , antibiotics , virology , biology , bacteria , escherichia coli , biochemistry , gene , physics , genetics , optics
Background: Typhoid fever (TF) caused by Salmonella Typhi remains a major public health problem in Kenya. A systematic surveillance in in two slum areas in Nairobi, revealed a crude incidence of TF of 247 cases per 100,000 person-years of observation (pyo), with highest rates in children 5–9 years old (596 per 100,000 pyo). Currently over a third of S. Typhi isolates are multidrug-resistant (MDR), and show reduced susceptibility to fluoroquinolones; the drugs of choice for treatment of MDR cases. The situation is worrying especially for resource-limited settings where the few remaining effective antimicrobials are either unavailable or too expensive to be afforded by the general public. The main objective of this study was to evaluate the trends in AMR among S. Typhi isolated from patients attending hospitals in Nairobi in the last 5 years.
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