Open AccessHypersensitivity pneumonitis due to high-dose colistin aerosol therapy
Author(s) -
Ka-I Leong,
Sharon Ong,
Huei Leng Chee,
W. Lee,
Andrea LayHoon Kwa
Publication year - 2010
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2010.08.001
Subject(s) - hypersensitivity pneumonitis , colistin , medicine , pneumonitis , aerosol , antibiotics , microbiology and biotechnology , meteorology , geography , lung , biology
We report a case of hypersensitivity pneumonitis, possibly due to aerosolized colistin therapy for severe multi-resistant Gram-negative pneumonia. Microbiological eradication was achieved with colistin therapy, which was stopped after 12 days in view of rising eosinophilia and possible lung fibrosis. The eosinophil count started to normalize 3 days after stopping colistin therapy and the patient was eventually weaned to minimal ventilatory support.
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