Prevalence of metabolic syndrome and estimated Framingham risk score among Brazilian HIV-infected patients

Body: Background: Recent studies suggest that HIV infection itself or combination ART (cART) were both associated with increased risk for cardiovascular disease (CVD). The 10-year Framingham risk score (FRS) is used to predict cardiovascular events in the non-HIV-infected patients, and its application in the HIV-infected subjects is under discussion. We evaluated the traditional CVD risk factors and metabolic syndrome (MS) components among HIV-infected patients ART-treated and ART-naïve. Methods: This was a cross-sectional study of HIV-infected subjects ART-treated (n=29), HIV-infected patients ART-naive (n=28) and controls without previous CVD events (n=32). Subjects were selected for common age range (20 to 69 years) from the Instituto de Infectologia Emilio Ribas, São Paulo. We assessed cardiovascular risk factors, HIV viral load, nadir CD4 count, high-sensivity C-reactive protein (hs-CRP) and plasma lipid concentrations. MS components included low LDL cholesterol, high triglycerides, high BMI, hypertension and diabetes. The statistical analysis were done using a SPSS 16.0. Results: