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Background and purpose Our goal was to determine fiber tract integrity in hippocampal sclerosis (HS) using diffusion tensor imaging (DTI) and to correlate white matter damage with other pathology in this disease.  Methods Twenty-six patients and eight controls were studied with DTI tractography for 8 pairs of white matter fiber tracts and 2 commissural tracts. Fractional anisotropy (FA) of the fiber tracts was compared with controls. The FA of select fiber tracts was also compared with change in T2 signal in the anterior temporal lobe (ATC), and the performance on neuropsychological tests.  Results In comparison with controls, subjects with left sided hippocampal sclerosis (L-HS) had 3 ipsilateral fiber tracts with decreased FA. The FA of fiber tracts was similar in right sided HS (R-HS) to controls. The ipsilateral inferior longitudinal fasciculus had a decrease in FA that correlated with the ATC (T2 signal change). The right superior longitudinal fasciculus had a decrease in FA proportional to lower performance on tests of memory and language.  Conclusion The subjects with L-HS had more extensive structural abnormalities involving white matter tracts, both ipsilateral and contralateral. In contrast, subjects with R-HS had limited changes in white matter integrity. Pathology of white matter appears to be involved in deficits associated with HS, including ATC and cognitive performance.

Diffusion tensor imaging correlates of hippocampal sclerosis and anterior temporal lobe T2 signal changes in pharmacoresistant epilepsy