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SummaryCalcifying fibrous tumor (CFT) is a rare and benign tumor. Histological features are hyalinized fibroblast-poor tissue, infiltrative inflammatory cells mainly composed of lymphocytes or plasma cells, and psammoma bodies or dystrophic calcification. The pathogenesis is unknown. We treated a 30-year-old man who suffered from abdominal pain, nausea and vomiting for 2 days. After X-ray examination, we did not find any ileus, hollow organ perforation or genitourinary tract abnormalities and therefore strongly suspected acute ruptured appendicitis. An appendectomy was therefore performed immediately. Multiple tumors were found during surgery, and pathological examination confirmed the diagnosis of CFT. After surgery, the previous symptoms were relieved and the patient recovered completely. However, another nodule in the greater omentum was found by a computed tomography abdominal scan 4 months later. For CFT with a large tumor and recurrent symptoms, we recommend complete excision as the best treatment. For a case of asymptomatic CFT with a small tumor, long-term follow-up should suffice

Multiple calcifying fibrous tumors in the small intestine and the mesentery