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Fecal immunochemical test (FIT) is a screening tool for detecting neoplastic lesions in asymptomatic patients. Colonoscopy is indicated in levels of FIT >100ngHb/ml.AimCompare the frequency of advanced adenomas (AA) in colonoscopy between asymptomatic subjects with FIT+ vs. symptomatic patients. Evaluate the level of bleeding of AA.Material and methodologyCross-sectional, observational study of 2829 consecutive patientes referred for colonoscopy. We collected clinic-demographic information, AA (size, topography, and histology) and FIT quantification. We included 2829 subjects who underwent colonoscopy.Statisticsχ2, Student's t-tests (0.05), one-way ANOVA and ANCOVA were performed for adjusted contrasts among lesions, gender, positive left colonic findings and age.ResultsGlobal rate of AA was 7.2%. Detection of AA was higher in average-risk asymptomatic subjects than in symptomatic (8.9 vs. 4.35%); no differences in age, sex or site of lesion was find. Group 1: (n=902). 105 AA (alone: 80.2%; ≤9mm: 27.2%; 10–15mm: 62.9% and ≥16mm: 9.9%) were detected in 81 patients (females: 38.2%; mean age: 64.1±8.4 years). Group 2: (n=1927). AA 105 in 84 (5.1%) in symptomatic patients.Quantitative FIT showed a correlation between AA size and bleeding level. For each mm that increased the size of the AA, the bleeding level increased 35±9ngHb with a stop limit of 15mm.ConclusionsDetection was higher in average-risk asymptomatic subjects with FIT+ than in symptomatic patients. Quantitative FIT showed a correlation between adenoma size and bleeding level

Usefulness of the fecal immunochemical test in the detection of advanced adenomas in subjects at average risk for colorectal cancer