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serum EPO levels positively correlated with circulating Cterminal (total) FGF23 concentrations (A), but not with circulating intact FGF23 concentrations (B). Figure S4. Associations between ferritin and fibroblast growth factor 23 (FGF23) in the autosomal dominant polycystic kidney disease (ADPKD) bone biopsy cohort. In patients with ADPKD, serum ferritin levels tended to inversely correlate with circulating C-terminal (total) FGF23 concentrations (A), but not with circulating intact FGF23 concentrations (B) or with bone FGF23 levels (C). Figure S5. Associations among iron-related parameters in autosomal dominant polycystic kidney disease (ADPKD) subjects. In patients with ADPKD, serum erythropoietin (EPO) levels positively correlated with erythroferrone (ERFE) (A), but ERFE did not correlate with hepcidin (B). Serum ferritin positively correlated with hepcidin (C). Table S1. Multiple linear regression modeling, dependent variable: log-transformed C-terminal (total) fibroblast growth factor 23 (FGF23) (n 1⁄4 78). Table S2. Multiple linear regression modeling, dependent variable: log-transformed intact fibroblast growth factor 23 (FGF23) (n 1⁄4 78). Table S3. Multiple linear regression modeling, dependent variable: C-terminal (total) fibroblast growth factor (FGF) 23, excluding outlying point (n 1⁄4 77). Table S4. Multiple linear regression modeling, dependent variable: intact fibroblast growth factor (FGF)23, excluding outlying point (n 1⁄4 77). Supplementary References. Supplementary Methods.

Elevated Fibroblast Growth Factor 23 Levels Are Associated With Greater Diastolic Dysfunction in ESRD