Open AccessProgressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition
Author(s) -
Nicholas MedjeralThomas,
Anne Troldborg,
Nicholas Constantinou,
Hannah J. Lomax-Browne,
Annette G. Hansen,
Michelle Willicombe,
Charles D. Pusey,
H. Terence Cook,
Steffen Thiel,
Matthew C. Pickering
Publication year - 2017
Publication title -
kidney international reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.225
H-Index - 22
ISSN - 2468-0249
DOI - 10.1016/j.ekir.2017.11.015
Subject(s) - medicine , serine protease , mannan binding lectin , nephropathy , lectin , masp1 , protease , serine , biochemistry , immunology , endocrinology , enzyme , chemistry , diabetes mellitus
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury.
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