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This work studies the impact of systematic uncertainties associated tointeraction cross sections on depth dose curves determined by Monte Carlosimulations. The corresponding sensitivity factors are quantified by changingcross sections in a given amount and determining the variation in the dose. Theinfluence of total cross sections for all particles, photons and only forCompton scattering is addressed. The PENELOPE code was used in all simulations.It was found that photon cross section sensitivity factors depend on depth. Inaddition, they are positive and negative for depths below and above anequilibrium depth, respectively. At this depth, sensitivity factors are null.The equilibrium depths found in this work agree very well with the mean freepath of the corresponding incident photon energy. Using the sensitivity factorsreported here, it is possible to estimate the impact of photon cross sectionuncertainties on the uncertainty of Monte Carlo-determined depth dose curves.

Impact of photon cross section systematic uncertainties on Monte Carlo-determined depth-dose distributions