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Partial cubes are graphs isometrically embeddable into hypercubes. We analyzehow isometric cycles in partial cubes behave and derive that every partial cubeof girth more than 6 must have vertices of degree less than 3. As a directcorollary we get that every regular partial cube of girth more than 6 is aneven cycle. Along the way we prove that every partial cube $G$ with girth morethan 6 is a tree-zone graph and therefore $2n(G)-m(G)-i(G)+ce(G)=2$ holds,where $i(G)$ is the isometric dimension of $G$ and $ce(G)$ its convex excess.

There are no finite partial cubes of girth more than 6 and minimum degree at least 3