English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This editorial refers to "Myocardial performance index, a Doppler-derived index of global left ventricular function, predicts congestive heart failure in elderly man" by J. Arnlov et al. on page 2220 and "The effects of changes in loading conditions and modulation of inotropic state on the myocardial performance index: comparison with conductance catheter measurements" by M.M.H. Cheung et al. on page 2238 † Clinicians are familiar with the diagnostic and prognostic implications of some of the cardiac intervals that are audible at the bedside. They usually result from myocardial or valvular events that are affected by function, haemodynamics, and electrical activity of the heart. Correctly auscultating an S4 or S3 gallop sound enables clinicians to diagnose abnormal myocardial relaxation, compliance, or both with elevated filling pressures.1 Because myocardial relaxation and contraction are orchestrated by intracellular recycling of calcium ions, the timing of these cardiac events is in fact related to the health of myocardial cells. The left ventricle is a pump with two interrelated functions2: systolic ejection and diastolic filling. Systolic ejection is preceded by isovolumic contraction and occurs at elevated pressures. Elevated pressures are a prerequisite for fast, efficient autoregulation of blood flow as a function of the metabolic needs of the organs under different working conditions. Diastolic filling is preceded by isovolumic relaxation and occurs at low pressures. These low pressures are necessary for the intimate contact between circulation and air in the pulmonary alveoli. The theoretically optimal pressure domain curve of the … * Correspondence to: Thierry C. Gillebert, MD, PhD, FESC, Department of Cardiovascular Medicine, University of Ghent, De Pintelaan, 185, 9000 Gent, Belgium. Tel.: +32 9 240 3481; fax: +32 9 240 4432 (E-mail: thierry.gillebert{at}ugent.be).

Time intervals and global cardiac function. Use and limitations