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HIV-1-specific CD8 + T cells are required for immune suppression of HIV-1 replication and elimination of the associated viral reservoirs. However, effective induction of functional HIV-1-specific CD8 + T cells from naïve cells remains problematic in the setting of human vaccine trials. In this study, we investigated priming of functional HIV-1-specific CD8 + T cells from naïve cells.

Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells