English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Metabolic stress, chronic vascular injury and cellular apoptosis are include either proteolytic cleavage or the budding off of membrane miconsidered as instrumentally connected in the pathogenesis of atherosclerosis and diabetes (Gistera and Hansson, 2017). The work from Mattisson et al. (Mattisson et al., 2017) sheds light on this potentially important pathway linking cell-mediated death and cardiovascular outcomes. The study spans translational science, fromdescribing an elegant laboratory technique using Fas ligand to induce apoptosis in peripheral blood mononuclear cells and demonstrating release of TNF receptor 1 (TNFR-1), TNF-related apoptosis-inducing ligand receptor 2 (TRAILR-2) and Fas, to studying the cell death receptor plasma levels in a large well-characterized prospective population. The initial experiment demonstrated the link between ligandinduced apoptosis in cells, and the release of soluble receptors for Fas, TNFR-1 and TRAILR-2 in vitro, thus justifying the future measurement of levels of soluble receptors as clinical biomarkers relating to apoptosis. The authors took the study forward in a subset of the Malmo Diet and Cancer Study (Berglund et al., 1993), with an impressive follow up period. This part of the study demonstrated that several cardiovascular classical risk factors (age, high body mass index, smoking and hypertension) as well as high triglycerides and low levels of high density lipoprotein, correlated with the studied markers of death receptor-activated apoptosis. Furthermore, the highest tertiles for all three soluble cellular death markers predicted which patients would go on to develop diabetes, with TRAILR-2 having an independent association after correction for other risk factors. In addition, patients with known diabetes exhibited raised levels of markers of receptoractivated apoptosis. Aside frompredicting incident diabetes, the highest levels of TRAILR-2 also independently predicted future cardiovascular death, incident myocardial infarction and stroke. It has become clear that metabolic risk factors and other exogenous causes of cellular stress lead to detrimental clinical events via multiple pathways (Ceriello and Motz, 2004). This paper shows that in vitro cellular stress on peripheral blood mononuclear cells and a pancreatic beta cell line leads to the release of soluble death receptors. The mechanism for death receptor release remains to be determined, but could

ebiomedicine

Markers of Apoptosis Predict Cardiovascular Outcomes and Point to ‘Response to Injury’ as a Common Pathway Leading to Diabetes and Cardiovascular Events