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Article history: Received 28 October 2016 Accepted 28 October 2016 Available online 29 October 2016 fasted rats and a rat model of type 2 diabetes. Furthermore, surgical denervation of the pancreas dramatically improved first-phase GSIS, glycemic control, and β-cell survival in a murine diabetic model. Decreased first-phase GSIS may be a common insulin secretion pattern during times of scarcity and type 2 diabetes. In this study, the authors suggested an interesting hypothesis that beta cells in diabetic

Hypothalamic AMP-activated Kinase Regulates Glucose-stimulated Insulin Secretion