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Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to &gt;8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effects.

A model system for studying superselective radiotherapy of lymph node metastasis in mice with swollen lymph nodes