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Hypoplastic left heart syndrome (HLHS), one of the most serious congenital heart defects, can be surgically paliated using 3 subsequent stages. Long-term results of this approach are reviewed in this study.MethodsFifty-two consecutive patients (pts.) operated for HLHS from 1999 to 2012 were evaluated retrospectively.ResultsNorwood stage I operation was performed at the median age of 6.5 days with a total mortality of 19%. Significant risk factor for death was lower weight at surgery (Cox proportional risk per 1g increase=0.997, CI 0.995–0.990, P<0.001). Between stages I and II, 15 catheter/surgical reintervention had to be carried out in 13 pts. (aortic arch narrowing in 10/13). Forty-two pts. underwent stage II operation at the median age of 6.8 months with a total mortality of 4.8% and 18 subsequent reinterventions in 13 patients. Finally, 26 patients aged median 3.9 years underwent stage III operation (total cavopulmonary connection) with a total mortality of 8%. The probability of survival at 1/5/10 years of age was 77/77/71%. At long-term follow up (median 7.8 years) 37 of the 38 surviving patients are in NYHA functional class I or II.ConclusionsDespite a highly centralized care, surgical treatment of HLHS is still associated with a significant mortality and morbidity. Long-term survivals, however, have an acceptable functional status during childhood corresponding to other groups of patients after surgical palliation for functionally single ventricle

Long-term results of children operated for hypoplastic left heart syndrome in Children's Heart Centre