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Thisrapid temporal change strongly suggests that some environ-mental factor(s) would have played a pivotal role in thedevelopment of IBD. Despite extensive research, the exactcause for IBD remains largely unknown. IBD is higher in thedeveloped countries, in people with higher social, economical,educationalandoccupationalstatus,andplaceswithimprovedhygienecondition.Rightnow,thisphenomenonisexplainedbythe “hygiene hypothesis”, which suggests that a reduction inmicrobesoftheguthascontributedtothedevelopmentofIBD.

The effect of dietary chemicals on gut bacteria and IBD demands further study