Open AccessThe association of Haptoglobin polymorphism with Crohn's disease in Israel
Author(s) -
Itay Maza,
Rachel MillerLotan,
Andrew P. Levy,
Shula Nesher,
Amir Karban,
Rami Eliakim
Publication year - 2008
Publication title -
journal of crohn s and colitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.277
H-Index - 80
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1016/j.crohns.2008.03.005
Subject(s) - haptoglobin , crohn's disease , immunology , disease , phenotype , medicine , pathogenesis , nod2 , gastroenterology , biology , genetics , gene
Haptoglobin is a α(2)-sialoglycoprotein with hemoglobin binding capacity. Functional differences between the Hp phenotypes with the Hp 1-1 protein being a superior anti-inflammatory to the Hp 2-2 protein have been identified. The aim of our study was to investigate the possible role of Hp polymorphism in the susceptibility to Crohn's disease and its clinical course.
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