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Prenatal COVID infection is one of the worst affected and least attendedaspects of the COVID-19 disease. Like other coronaviruses, CoV2 infection isanticipated to affect fetal development by maternal inflammatory response onthe fetus and placenta. Studies showed that higher prenatal choline level inmother's body can safeguard the developing brain of the fetus from the adverseeffects of CoV2 infection. Choline is commonly used as food supplement. Byvirtual screening, molecular docking and molecular dynamics techniques, we haveestablished a strong inhibitory possibility of choline for SARS$\rm{3CL^{pro}}$ protease which may provide a lead for prenatal COVID-19treatment.

chemical physics letters

Neuroprotective Immunity by Essential Nutrient "Choline" for the  Prevention of SARS CoV2 Infections: An in Silico Study by Molecular Dynamics  Approach