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{\it Caenorhabditis elegans} nematode worms are the only animals with theknown detailed neural connectivity diagram, well characterized genomics, andrelatively simple quantifiable behavioral output. With this in mind, manyresearchers view this animal as the best candidate for a systems biologyapproach, where one can integrate molecular and cellular knowledge to gainglobal understanding of worm's behavior. This work reviews some research inthis direction, emphasizing computational perspective, and points out somesuccesses and challenges to meet this lofty goal.

Deciphering neural circuits for Caenorhabditis elegans behavior by computations and perturbations to genome and connectome