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Anti-staphylococcal penicillins (ASPs) are recommended as first-line agentsin methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. Concernsabout their safety profile have contributed to the increased use of cefazolin.The comparative clinical effectiveness and safety profile of cefazolin versusASPs for such infections remain unclear. Furthermore, uncertainty persistsconcerning the use of cefazolin due to controversies over its efficacy in deepMSSA infections and its possible negative ecological impact.

Cefazolin versus anti-staphylococcal penicillins for treatment of methicillin-susceptible Staphylococcus aureus bacteraemia: a narrative review