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The acceptance and respect of the rules governing society and the family unit are essential pillars for the development of a therapeutic program for people with substance dependence disorders. This study proposes a double objective using the scales of the MMPI-2 detectors of mismatches emphasising: what information can provide and what the diagnostic accuracy of the MMPI-2 is to assess these mismatches. As a reference, psychopathic deviation (Pd), social introversion (Si), antisocial practices (ASP), social responsibility (Re), social unrest (SOD), introversion/low positive emotion (PSY-INTR), family problems (FAM), and conjugal stress (MDS) were taken. Of the 226 participants, 113 are people with substance dependence and 113 have no dependence or any pathology. Their differences and diagnostic accuracy through the ROC curve were analysed. The results showed different contribution and diagnostic accuracy of the scales

La precisión diagnóstica del MMPI-2 al evaluar los desajustes socio-familiares en personas con dependencia de sustancias