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Leukocyte adhesion requires β 2 -integrin activation. Resting integrins exist in a bent-closed conformation-i.e., not extended (E - ) and not high affinity (H - )-unable to bind ligand. Fully activated E + H + integrin binds intercellular adhesion molecules (ICAMs) expressed on the opposing cell in trans. E - H - ransitions to E + H + hrough E + H - or through E - H + , which binds to ICAMs on the same cell in cis. Spatial patterning of activated integrins is thought to be required for effective arrest, but no high-resolution cell surface localization maps of activated integrins exist. Here, we developed Super-STORM by combining super-resolution microscopy with molecular modeling to precisely localize activated integrin molecules and identify the molecular patterns of activated integrins on primary human neutrophils. At the time of neutrophil arrest, E - H + integrins face each other to form oriented (non-random) nanoclusters. To address the mechanism causing this pattern, we blocked integrin binding to ICAMs in cis, which significantly relieved the face-to-face orientation.

High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis