Open AccessFixing a Hole Where the Ras Gets In
Author(s) -
Jeffrey S. Iwig,
John Kuriyan
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.05.029
Subject(s) - biology , small molecule , cancer research , signal transduction , gtp' , drug discovery , gtpase , small gtpase , guanosine , microbiology and biotechnology , computational biology , biochemistry , enzyme
A clinically efficacious Ras inhibitor has eluded drug-discovery efforts for decades. In a paper in Nature, Zimmermann and et al. show that blocking a hole in PDEδ that normally engages the lipid tail of Ras disrupts downstream signaling, pointing to a potentially promising route to develop Ras inhibitors for cancer treatment.
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