Open AccessFasting glucose and its association with 20‐year all‐cause and cause‐specific mortality in Chinese general population
Author(s) -
Zhou Long,
Mai JinZhuang,
Li Ying,
Wu Yong,
Guo Min,
Gao XiangMin,
Wu YangFeng,
Zhao LianCheng,
Liu XiaoQing
Publication year - 2019
Publication title -
chronic diseases and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2589-0514
DOI - 10.1016/j.cdtm.2018.08.001
Subject(s) - medicine , hazard ratio , body mass index , proportional hazards model , confidence interval , blood pressure , population , cause of death , disease , demography , environmental health , sociology
Objective The aim of this study was to explore the relationship between fasting glucose levels and all‐cause and cause‐specific mortality in Chinese population. Methods The role of fasting blood glucose levels as a predictor of all‐cause and cause‐specific mortality was estimated in 9930 participants from four Chinese general populations with a 20‐year follow‐up. Multivariate Cox proportional hazard models were used to identify the relationship between fasting glucose and mortality. Results There were 1471 deaths after a median follow‐up of 20.2 years (a total of 187,374 person‐years), including 310 cardiovascular deaths, 581 cancer deaths, and 580 other‐cause deaths. After adjustment for age, sex, urban or rural, northern or southern of China, types of work, education level, physical exercise, smoking status, drinking status, body mass index, systolic blood pressure, and serum total cholesterol at baseline, the hazard ratios ( HR s) and 95% confidence intervals ( CI s) for all‐cause mortality in the fasting blood glucose categories of <60, 60–69, 70–79, 90–99, 100–109, 110–125, and ≥126 mg/dl were 1.38 (1.04–1.84), 1.20 (1.01–1.43), 1.18 (1.03–1.36), 1.18 (0.99–1.41), 1.48 (1.16–1.88), 1.17 (0.84–1.62), and 2.23 (1.72–2.90), respectively, in contrast to the reference group (80–89 mg/dl). The HR s and 95% CI s for cardiovascular disease mortality in these groups were 2.58 (1.44–4.61), 1.41 (0.95–2.10), 1.56 (1.15–2.11), 1.29 (0.88–1.89), 1.36 (0.78–2.37), 1.05 (0.52–2.11), and 2.73 (1.64–4.56), respectively. Conclusions Both low and high fasting glucose were significantly associated with increased risk of all‐cause and cardiovascular mortality in Chinese general population.