Open AccessCurrent advances in circulating inflammatory biomarkers in atherosclerosis and related cardio‐cerebrovascular diseases
Author(s) -
Lv JunXuan,
Kong Qi,
Ma Xin
Publication year - 2017
Publication title -
chronic diseases and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2589-0514
DOI - 10.1016/j.cdtm.2017.09.002
Subject(s) - medicine , inflammation , plasminogen activator , von willebrand factor , disease , immunology , bioinformatics , biology , platelet
Atherosclerosis (AS) is a systemic chronic disease affecting both the coronary and cerebral arteries. Inflammation plays a key role in the initiation and progression of AS, and numerous inflammatory factors have been proposed as potential biomarkers. This article reviews recent research in studies on major circulating inflammatory biomarkers to identify surrogates that may reflect processes associated with AS development and the risk of AS‐related vascular events, such as Von Willebrand factor, lectin‐like oxidized low‐density‐lipoprotein receptor‐1, soluble urokinase plasminogen activator receptor, regulated upon activation, normal T‐cell expressed and secreted, and microparticles, which may provide new perspectives for clinical AS evaluation and risk stratification.