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A recent paper in Cardiovascular Research from Hove-Madsen and colleagues [1] has investigated the role of the adenosine A2A receptor in human atrial myocytes. Elegant confocal images show that this receptor is localized at the level of the Z line in the myocyte. Their paper then proceeds to address an important physiological question; the role of this receptor. No effect was found on the amplitude or voltage-dependence of the L-type Ca current. However agonists of the adenosine A2A receptor increased the frequency of both Ca sparks and Ca waves, phenomena that result from Ca induced Ca release (CICR) from the sarcoplasmic reticulum (SR). There was no change in either the amount of Ca extruded from the cell during each Ca wave or the SR Ca content (as assessed by the integral of the caffeine evoked Na–Ca exchange, NCX, current). Based on these …

Does the adenosine A2A receptor stimulate the ryanodine receptor?