Open AccessRegulating cellular oxygen sensing by hydroxylation
Author(s) -
Joachim Fandrey,
Thomas A. Gorr,
Max Gassmann
Publication year - 2006
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1016/j.cardiores.2006.05.005
Subject(s) - regulator , hypoxia (environmental) , transcription factor , microbiology and biotechnology , master regulator , hydroxylation , hypoxia inducible factors , homeostasis , biology , hypoxia inducible factor 1 , oxygen , chemistry , gene , biochemistry , enzyme , organic chemistry
Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.
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