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See article by Jung et al. [11] (pages 76–85) in this issue. “To lengthen thy Life, lessen thy Meals.” Benjamin Franklin, Poor Richard's Almanack, 1733 The burden of chronic diseases is on the rise on all continents, and the predictions for its detrimental effects on the individual and society resemble the warnings of a hurricane approaching land [1]. Most of the storm settles on complications of cardiovascular disease, the risk of which is increased by a factor of two to three even by the clustering of “prestages” of traditional cardiovascular factors, referred to as the “metabolic syndrome” and related to insulin resistance ever since Reaven's seminal work in 1987 [2]. Five different major sets of criteria are currently in place for the diagnosis of the metabolic syndrome, with the entire concept being very critically appraised by representatives of American and European diabetes societies, yet again endorsed by the American Heart Association, and with a worldwide definition by the International Diabetes Federation appearing on the horizon [3,4]. The most apparent underlying risk factor for the metabolic syndrome is truncal or visceral obesity and hence waist circumference or waist-to-hip ratio are better clinical parameters than body mass index [3]. Hence, as society is “supersizing” so is the risk of cardiovascular diseases and the call to the cardiovascular practice and research community.Once considered to serve no other purpose than to store energy, adipose tissue has been increasingly recognized as an active endocrine organ, capable of synthesizing and secreting so-called adipokines. One of the 21st century editions of these substances is resistin, a 12.5-kDa, 114-amino acid polypeptide, rich in cysteine residues, that can form dimers and hexamers in the new family of resistin-like molecules [5,6]. The name “resistin” is derived from its discovery in the search for a … *Tel.: +1 507 255 5890; fax: +1 507 255 1824. Email address: herrmann.joerg{at}mayo.edu

Large meals and large arteries: Is resistin the link?