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Traffic of potentially harmful cytosolic messengers through gap junctions might cause increased injury during ischemia. The present study was to determine whether the infarct size-reducing effect of adjunctive estradiol administration prior to reperfusion is associated with an attenuated expression of connexin43 at the border of infarction in a canine model.

Adjunctive 17β-estradiol administration reduces infarct size by altered expression of canine myocardial connexin43 protein