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We are grateful for the comments of Razeghi et al. elicited by our recent report [1] on the important issue of comparability of experimental data raised from myocardial tissue samples among different studies on cardiac reverse remodeling under LVAD support. We completely agree that there are a number of non-standardized parameters among the different studies published thus far that make the direct comparison of experimental data difficult. These include patient characteristics and the underlying cause of heart failure as well as the make, duration and degree of LVAD support. In addition, we wish to emphasize another critical issue missing in most studies published thus far in the literature (with exceptions such as a study by Ragehzi et al. [2]): the lack of positive or negative correlative data between experimental findings and the clinical condition of the patients before and during LVAD support. Cardiac function parameters such as echocardiography, pulmonary artery and capillary wedge pressure are rarely mentioned, and are not correlated with the experimental data from myocardial tissue samples. Neither is the clinical follow-up or outcome of the LVAD-supported patients elaborated in most studies. However, it is just this attempt to associate clinical with experimental findings that is crucial for differentiating between causal and epiphenomenal observations in the pathophysiological process of cardiac …

Experimental and clinical parameters of cardiac reverse remodeling after LVAD support: a call for uniformity